Hot off the press. NY state just approved five more companies to grow and distribute medical marijuana. Here’s the article from Marijuana Business Daily.
This is good news for patients: the more competition, the lower the price. NY prices are at least 3x West Coast prices per mg of THC. Props to NYS for making this vital medicine more available to its citizens.
High Times reports that an international team of researchers has actually figured out how the CB1 receptors in your brain respond to THC and other medicines that bind to them. It turns out that your CB1 receptors have way different structures depending on which medicine is actually binding to it. Here’s the article in Nature.
This information is important because when THC or any other medicine binds onto a CB1 receptor, we can now start looking at how different shapes of this complex cause different behaviors in your brain cells. This is an obvious guideline to choosing or designing medicines with specific effects on the CB1 receptor. This is very exciting stuff, and not just for geeks.
Go Science ! ! !
A lot of our patients would like to find a vaporizer that is inexpensive and easy to use. The XEO VOID seems to fit this bill. It’s about $60 online, has great reviews from the vaping community, and seems to be really easy to use. You just stand it up, unscrew the top, and add your vaping oil. Easy.
Vireo has just come out with a 1 ml oil product with about 400 mg of THC . This is a “refill” for vape pens, and delivers vaped THC for around 30-35 cents per milligram, way inexpensive vaped THC in NYS. Last we heard the price was around $130-135.
Here’s a link to the XEO VOID , easy to use vape pen for around $60.
So for under $200, you can get your vape pen and 1 ml of THC vape oil. So you buy the vape oil, load up the vape pen, and you are good to go. For under 200 bucks. Just sayin’.
Here’s a tip from one of our patients who happens to be a nurse. Nurses are really smart.
Since liquid THC works great but tastes terrible, this is how you take it:
- take the dropper and put the medicine UNDER your tongue
- then grab a glass of water and take a drink
That’s it. The water that you sip from the glass washes the liquid THC past your taste buds and it is not nearly as vile tasting.
Nurses Rule ! ! !
So you have THC or CBD in capsule form and one capsule is a little strong for you. What to do? Well , you could go back and buy the liquid and just take fewer ml but that would get expensive.
Here’s a trick: put your capsules in the freezer for an hour or so, then cut the frozen capsules in half (put them back in the freezer). The liquid inside the capsules may just harden enough to let you get away with this.
There is always a way…
If oral THC is not working, try vaping the THC.
We now have good data on about 150 results and some really interesting stuff is shaking down.
At least five folks get very little results from THC that they take by mouth, but they get GREAT results from THC that they vape. This works out to around 7% of folks who respond to THC at all.
There is an explanation for this.
It turns out that when you inhale THC, you are getting the delta-9-tetrahydrocannabinol directly into your bloodstream. This is the chemical that your brain/body see when medical marijuana is vaped.
However, when you EAT your THC product, your liver transforms the eaten THC into 11-hydroxy-delta-9-tetrahydrocannabinol as the predominant chemical that your brain/body see.
And it turns out that about 1/15 folks respond well to vaping delta-9-THC but don’t respond well to its 11-hydroxy-THC cousin they get from eating THC.
All this stuff is in progress, so Watch This Space.
Here is an article that brings up a really interesting idea: cannabinoid deficiency as contributing to disease. Medical marijuana works on the endocannabinoid systems that are everywhere in our bodies. We know that we get sick when other chemical signaling systems in our bodies are underperforming: Parkinson’s Disease and dopamine systems, depression and serotonin systems. Sooooo, might an underperforming endocannabinoid system contribute to common health problems like chronic pain, Crohn’s disease?
So we don’t have any answers yet, but we may be starting to ask the right questions. Watch This Space.
We know that medical marijuana can help with chemotherapy related nausea and weight loss. Here’s an article from British Journal of Pharmacology that helps explain why.
It turns out that if you hit your brain’s CB1 receptors with THC and make that effect stick around with CBD, you can way decrease chemotherapy related nausea and weight loss. So we think that both THC and CBD should be tried to prevent chemotherapy related nausea and weight loss.
Here is an article with an overview of medical marijuana for chronic pain. Lots of studies are linked to.
Here’s an image from leafscience.com showing the endocannabinoid receptors that THC and CBD modulate.
In short, both the THC and CBD in medical marijuana can help folks with chronic pain live their lives better. A lot of folks would rather NOT take their opiate pain medicine, if only they could find an effective alternative. I think our NYS legislators need to hear about this, don’t you?