CBD bioavailability and you

Some of our patients have a great response to CBD alone or in combination with THC for their pain or other symptoms.  Some other patients either have no response or have side effects from CBD taken by mouth. So what gives?

We’ve been thinking a lot about CBD bioavailability.  Basically this concept asks how much CBD your body actually absorbs from whatever CBD you take by mouth or inhalation.  There is a great review paper on this topic and a lot of really useful info can be gleaned from it.

First, if you take CBD by mouth your body might only get 1% of the total amount you ate. So a 20 mg CBD capsule might deliver only 0.2 mg of CBD to your bloodstream.

Second, CBD bioavailability is very variable between people. Your friend may absorb 10% of the CBD they eat, but you might only absorb 0.1% of the same CBD that you eat. So maybe “I’m not responsive to CBD ” might really mean “My body just doesn’t absorb CBD from my gut.”

We know that the bioavailability of inhaled (eg vaped) CBD is around 30%. So if you vape 1 mg of CBD in a hit, your body sees 0.3 mg of that vaped CBD. This is way more than your body might see from  20 mg of CBD that you take by mouth.

So maybe if CBD taken by mouth either does not work for you or causes you side effects like indigestion, you might want to try vaping your CBD.

One source for such a vape that some people find helpful is the cbd store . Although we can not recommend it, we can inform you that there is a CBD vape cartridge/pen combination on this site. The 400 mg Pure Ratios CBD vape cartridge costs around $80 and the pen itself is $20. At around 250 hits per ml, this would deliver around 1.6 mg CBD per vape hit  At 30% bioavailability your body would see  around 0.48 mg of CBD per vape hit. So 3 vape hits per day might give you, on average, way more CBD than three  20 mg CBD capsules would. And the vape cartridge would last over 2 months.  Just information.

 

vaporizer that has good reviews

xeo_void

A lot of our patients would like to find a vaporizer that is inexpensive and easy to use. The XEO VOID seems to fit this bill. It’s about $60 online, has great reviews from the vaping community, and seems to be really easy to use. You just stand it up, unscrew the top, and add your vaping oil. Easy.

Freeze your capsules !!

So you have THC or CBD in capsule form and one capsule is a little strong for you. What to do? Well , you could go back and buy the liquid and just take fewer ml but that would get expensive.

Here’s a trick: put your capsules in the freezer for an hour or so, then cut the frozen capsules in half (put them back in the freezer). The liquid inside the capsules may just harden enough to let you get away with this.

There is always a way…

Call your congressman NOW !

The DEA has just declared CBD to be a Schedule I drug.

dea_cbd

Here’s the Federal Register notice: as of 13 Jan 2017, possession of CBD will be treated just like possession of heroin.  There has been NO effective public discussion of this matter, and one obvious conclusion is that pharmaceutical industry pressure caused this change in long-accepted policy.

That means that CBD, which has been available online for years, can no longer be obtained from reputable firms that produce it.

Call (MAKE A PHONE CALL) your congressman NOW !!!

Call the local office, not the DC office. Be Very Loud.

No emails, no text messages: a loud irate PHONE CALL is needed TODAY.

Sample message:
I have a problem that my representative/senator needs to fix. The DEA just put out a rule up-scheduling CBD, the non-psychoactive part of the marijuana plant, to Schedule I, the same as heroin.  This is harming me and other patients who can get CBD by mail order safely and inexpensively.  This rule needs to be changed back to the current law, which has worked just fine. What will my representative/senator do about this?

The DEA needs to feel pressure from the Americans that it has harmed by this riduculous rule change. Pick up your phone and get your friends and relatives to pick up theirs. Use your power as a citizen. I just called my representative and senators. You do too.

REPRESENTATIVES local DC
John Katko ny 24: syr 315 423 5657 202 225 3701
Elise Stefanik ny 21: north country 518 743 0964 202 225   4611
Tom Reed ny 23: ithaca 607 222 2227 202 225   3161
Richard Hanna ny 22: Utica, binghamton 315 724 9740 202 225    3665
Louise Slaughter ny 25: Rochester 585 232 4850 202 225    3615
Paul Tonko ny 20: albany 518 465 0700 202 225    5076
SENATORS
Charles Schumer  

(315) 423-5471

 

202 224 6542
Kirsten Gillibrand 315 448 0470 202 224 4451

CBD almost never shows up on urine drug tests

Here’s an article about whether CBD will show up on a urine drug test. The short answer is almost never.  If you take 1-2 grams of CBD per day, the CBD metabolites may react positive on the initial screen, but subsequent testing with GC/MS technique will exclude THC.

cbd_pee

This is another reason to obtain your CBD  from reputable sources.

Disclaimer:

As practitioners in the NYS Medical Marijuana Program, we can only recommend that you obtain your CBD from NYS approved dispensaries.

 

Cannabinoid deficiency: let’s think about this

Here is an article that brings up a really interesting idea: cannabinoid deficiency as contributing to disease.  Medical marijuana works on the endocannabinoid systems that are everywhere in our bodies.  We know that we get sick when other chemical signaling systems in our bodies are underperforming: Parkinson’s Disease and dopamine systems, depression and serotonin systems.  Sooooo, might an underperforming endocannabinoid system contribute to common health problems like chronic pain, Crohn’s disease?

cann_deficiency

So we don’t have any answers yet, but we may be starting to ask the right questions. Watch This Space.

Nausea and the CB1 receptors

We know that medical marijuana can help with chemotherapy related nausea and weight loss.  Here’s an article from British Journal of Pharmacology that helps explain why.

cb1_nausea

It turns out that if you hit your brain’s CB1 receptors with THC and make that effect stick around with CBD, you can way decrease chemotherapy related nausea and weight loss.  So we think that both THC and CBD should be tried to prevent chemotherapy related nausea and weight loss.