The actual structure of CB1 receptors is getting mapped. Here’s an article that points to some really cool basic science research that is beginning to sort out how and where THC and other cannabinoids work to switch on the CB1 receptors.
This is really exciting stuff for all kinds of reasons. First, we get to learn how THC works at a detailed molecular level. Second, we may be able to design more specific cannabinoids to do exactly what we want and not do what we don’t want. Watch This Space.