Receptor heterogeneity and marijuana effects (geeky)

Here’s an article that reports a common set of events. Two people take the same medical marijuana product and have two completely different experiences.  Same stuff, same dose, same everything. But way different outcomes. Why is that?  To quote Facebook, it’s complicated.  First, the endocannabinoid receptors are different in different people (aka “receptor heterogeneity”) . They grab onto THC in different ways with differing “tightness” of binding.  Then CBD can affect FAAH, then enzyme that degrades cannabinoids, differently in different people.

receptor_hetero

Still here? Sorry, but that’s only the endocannabinoid system.  We know that the endocannabinoid system affects other chemical signalling systems (eg GABA-nergic transmission) differently in different people.  So it’s really complicated.

The upshot is that it’s basically impossible to predict for any one person whether any one medical marijuana medicine will work, and how it will work.  You just have to try it with your recommender in the loop.  Start slow, add gradually, keep a diary.